The Department of Surgery

The University of Chicago

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Jeffrey Matthews, MD

Physician Profile

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General Surgery
Professor of Surgery
Dallas B. Phemister Professor and Chair of Surgery
O220; MC 5029

Clinical Interests:
- Gastrointestinal and hepatobiliary/pancreatic surgery
- Obesity
- Inflammatory bowel disease
- Gastro-intestinal oncology

Academic Interests:

Research focuses on fundamental mechanisms of regulation of epithelial chloride secretion, the transport event underlying the clinical manifestations of cystic fibrosis and numerous digestive disorders characterized by diarrhea. Current funding includes projects examining the regulation of Na-K-2Cl cotransporter function and expression, the impact of ammonia and ammonia-derived oxidants on intestinal function, and the role of purinergic compounds in the epitheial response to metabolic stress. particular emphasis is placed on the role of the actin-based cytoskeleton in cell signaling as it relates to integral membrane transport protein function and tight junctional integrity. Novel approaches to anti-diarrheal therapy and to therapy of cystic fibrosis are suggested by various projects within the laboratory

Education:
M.D.: Harvard University, Boston, MA
Fellowship: University of Bern, Bern, Hepatobiliary Surgery
Residency: Beth Israel Hospital, Boston, MA
Fellowship: Brigham and Women's Hospital, Boston, MA Pathology

Representative Publications:
Year Started in Practice:1992 

Practice Location(s):5841 S. Maryland Ave.
Chicago, IL 60637 
Memberships:Association for Academic Surgery
American Gastroenterological Association
American Physiological Society
American College of Surgeons
Society of University Surgeons
Society for Surgery of the Alimentary Tract
American Pancreatic Association
American Board of Surgery
Gastroenterology Research Group
American Society for Clinical Investigation
American Association for the Advancement of Science
American Hepato-Pancreato-Biliary Association
Association of Program Directors in Surgery
American Society for Bariatric Surgery
Society of Clinical Surgery 
Languages Spoken:English 


Published Works